Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.
Identifieur interne : 000192 ( Main/Exploration ); précédent : 000191; suivant : 000193Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.
Auteurs : Rene Garcia-Contreras [Japon] ; Rogelio J. Scougall-Vilchis [Mexique] ; Rosalia Contreras-Bulnes [Mexique] ; Yumiko Kanda [Japon] ; Hiroshi Nakajima [Japon] ; Hiroshi Sakagami [Japon]Source :
- In vivo (Athens, Greece) [ 1791-7549 ]
Descripteurs français
- KwdFr :
- Antinéoplasiques (composition chimique), Antinéoplasiques (pharmacologie), Antinéoplasiques (toxicité), Ciment ionomère au verre (composition chimique), Ciment ionomère au verre (pharmacologie), Ciment ionomère au verre (toxicité), Dinoprostone (biosynthèse), Humains (MeSH), Lignée cellulaire tumorale (MeSH), Nanoparticules (administration et posologie), Nanoparticules (composition chimique), Relation dose-effet des médicaments (MeSH), Survie cellulaire (effets des médicaments et des substances chimiques), Titane (administration et posologie), Tumeurs de la bouche (métabolisme), Tumeurs de la bouche (ultrastructure).
- MESH :
- administration et posologie : Nanoparticules, Titane.
- biosynthèse : Dinoprostone.
- composition chimique : Antinéoplasiques, Ciment ionomère au verre, Nanoparticules.
- effets des médicaments et des substances chimiques : Survie cellulaire.
- métabolisme : Tumeurs de la bouche.
- pharmacologie : Antinéoplasiques, Ciment ionomère au verre.
- toxicité : Antinéoplasiques, Ciment ionomère au verre.
- ultrastructure : Humains, Lignée cellulaire tumorale, Relation dose-effet des médicaments, Tumeurs de la bouche.
English descriptors
- KwdEn :
- Antineoplastic Agents (chemistry), Antineoplastic Agents (pharmacology), Antineoplastic Agents (toxicity), Cell Line, Tumor (MeSH), Cell Survival (drug effects), Dinoprostone (biosynthesis), Dose-Response Relationship, Drug (MeSH), Glass Ionomer Cements (chemistry), Glass Ionomer Cements (pharmacology), Glass Ionomer Cements (toxicity), Humans (MeSH), Mouth Neoplasms (metabolism), Mouth Neoplasms (ultrastructure), Nanoparticles (administration & dosage), Nanoparticles (chemistry), Titanium (administration & dosage).
- MESH :
- chemical , administration & dosage : Titanium.
- chemical , biosynthesis : Dinoprostone.
- chemical , chemistry : Antineoplastic Agents, Glass Ionomer Cements.
- chemical , pharmacology : Antineoplastic Agents, Glass Ionomer Cements.
- chemical , toxicity : Antineoplastic Agents, Glass Ionomer Cements.
- administration & dosage : Nanoparticles.
- chemistry : Nanoparticles.
- drug effects : Cell Survival.
- metabolism : Mouth Neoplasms.
- ultrastructure : Mouth Neoplasms.
- Cell Line, Tumor, Dose-Response Relationship, Drug, Humans.
Abstract
BACKGROUND/AIM
Incorporation of nanoparticles (NPs) into the glass ionomer cements (GICs) is known to improve their mechanical and antibacterial properties. The present study aimed to investigate the possible cytotoxicity and pro-inflammation effect of three different powdered GICs (base, core build and restorative) prepared with and without titanium dioxide (TiO2) nanoparticles.
MATERIALS AND METHODS
Each GIC was blended with TiO2 nanopowder, anatase phase, particle size <25 nm at 3% and 5% (w/w), and the GIC blocks of cements were prepared in a metal mold. The GICs/TiO2 nanoparticles cements were smashed up with a mortar and pestle to a fine powder, and then subjected to the sterilization by autoclaving. Human oral squamous cell carcinoma cell lines (HCS-2, HSC-3, HSC-4, Ca9-22) and human normal oral cells [gingival fibroblast (HGF), pulp (HPC) and periodontal ligament fibroblast (HPLF)] were incubated with different concentrations of GICs in the presence or absence of TiO2 nanoparticles, and the viable cell number was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Prostaglandin E2 was quantified by enzyme-linked immunosorbent assay (ELISA). Changes in fine cell structure were assessed by transmission electron microscopy.
RESULTS
Cancer cells exhibited moderate cytotoxicity after 48 h of incubation, regardless of the type of GIC and the presence or absence of TiO2 NPs. GICs induced much lower cytotoxicity against normal cells, but induced prostaglandin E2 production, in a synergistic wanner with interleukin-1β.
CONCLUSION
The present study shows acceptable to moderate biocompatibility of GICs impregnated with TiO2 nanoparticles, as well as its pro-inflammatory effects at higher concentrations.
PubMed: 25189906
Affiliations:
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Scougall-Vilchis</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthodontics, Faculty of Dentistry, Autonomous University State of Mexico, Toluca, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Orthodontics, Faculty of Dentistry, Autonomous University State of Mexico, Toluca</wicri:regionArea><wicri:noRegion>Toluca</wicri:noRegion></affiliation></author><author><name sortKey="Contreras Bulnes, Rosalia" sort="Contreras Bulnes, Rosalia" uniqKey="Contreras Bulnes R" first="Rosalia" last="Contreras-Bulnes">Rosalia Contreras-Bulnes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pediatric Dentistry, Faculty of Dentistry, Autonomous University State of Mexico, Toluca, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Department of Pediatric Dentistry, Faculty of Dentistry, Autonomous University State of Mexico, Toluca</wicri:regionArea><wicri:noRegion>Toluca</wicri:noRegion></affiliation></author><author><name sortKey="Kanda, Yumiko" sort="Kanda, Yumiko" uniqKey="Kanda Y" first="Yumiko" last="Kanda">Yumiko Kanda</name><affiliation wicri:level="1"><nlm:affiliation>Department of Electron Microscopy, Meikai University School of Dentistry, Sakado, Saitama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Electron Microscopy, Meikai University School of Dentistry, Sakado, Saitama</wicri:regionArea><wicri:noRegion>Saitama</wicri:noRegion></affiliation></author><author><name sortKey="Nakajima, Hiroshi" sort="Nakajima, Hiroshi" uniqKey="Nakajima H" first="Hiroshi" last="Nakajima">Hiroshi Nakajima</name><affiliation wicri:level="1"><nlm:affiliation>Division of Dental Biomaterials Science, Meikai University School of Dentistry, Sakado, Saitama, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Dental Biomaterials Science, Meikai University School of Dentistry, Sakado, Saitama</wicri:regionArea><wicri:noRegion>Saitama</wicri:noRegion></affiliation></author><author><name sortKey="Sakagami, Hiroshi" sort="Sakagami, Hiroshi" uniqKey="Sakagami H" first="Hiroshi" last="Sakagami">Hiroshi Sakagami</name><affiliation wicri:level="1"><nlm:affiliation>Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan sakagami@dent.meikai.ac.jp dentist.garcia@gmail.com.</nlm:affiliation><country wicri:rule="url">Japon</country><wicri:regionArea>Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama</wicri:regionArea><wicri:noRegion>Saitama</wicri:noRegion></affiliation></author></analytic><series><title level="j">In vivo (Athens, Greece)</title><idno type="eISSN">1791-7549</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antineoplastic Agents (chemistry)</term><term>Antineoplastic Agents (pharmacology)</term><term>Antineoplastic Agents (toxicity)</term><term>Cell Line, Tumor (MeSH)</term><term>Cell Survival (drug effects)</term><term>Dinoprostone (biosynthesis)</term><term>Dose-Response Relationship, Drug (MeSH)</term><term>Glass Ionomer Cements (chemistry)</term><term>Glass Ionomer Cements (pharmacology)</term><term>Glass Ionomer Cements (toxicity)</term><term>Humans (MeSH)</term><term>Mouth Neoplasms (metabolism)</term><term>Mouth Neoplasms (ultrastructure)</term><term>Nanoparticles (administration & dosage)</term><term>Nanoparticles (chemistry)</term><term>Titanium (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antinéoplasiques (composition chimique)</term><term>Antinéoplasiques (pharmacologie)</term><term>Antinéoplasiques (toxicité)</term><term>Ciment ionomère au verre (composition chimique)</term><term>Ciment ionomère au verre (pharmacologie)</term><term>Ciment ionomère au verre (toxicité)</term><term>Dinoprostone (biosynthèse)</term><term>Humains (MeSH)</term><term>Lignée cellulaire tumorale (MeSH)</term><term>Nanoparticules (administration et posologie)</term><term>Nanoparticules (composition chimique)</term><term>Relation dose-effet des médicaments (MeSH)</term><term>Survie cellulaire (effets des médicaments et des substances chimiques)</term><term>Titane (administration et posologie)</term><term>Tumeurs de la bouche (métabolisme)</term><term>Tumeurs de la bouche (ultrastructure)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Titanium</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Dinoprostone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antineoplastic Agents</term><term>Glass Ionomer Cements</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antineoplastic Agents</term><term>Glass Ionomer Cements</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Antineoplastic Agents</term><term>Glass Ionomer Cements</term></keywords><keywords scheme="MESH" qualifier="administration & dosage" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Nanoparticules</term><term>Titane</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Dinoprostone</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Nanoparticles</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Antinéoplasiques</term><term>Ciment ionomère au verre</term><term>Nanoparticules</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Survival</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Survie cellulaire</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mouth Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Tumeurs de la bouche</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques</term><term>Ciment ionomère au verre</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Antinéoplasiques</term><term>Ciment ionomère au verre</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Mouth Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>Dose-Response Relationship, Drug</term><term>Humans</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="fr"><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Relation dose-effet des médicaments</term><term>Tumeurs de la bouche</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND/AIM</b></p><p>Incorporation of nanoparticles (NPs) into the glass ionomer cements (GICs) is known to improve their mechanical and antibacterial properties. The present study aimed to investigate the possible cytotoxicity and pro-inflammation effect of three different powdered GICs (base, core build and restorative) prepared with and without titanium dioxide (TiO2) nanoparticles.</p></div><div type="abstract" xml:lang="en"><p><b>MATERIALS AND METHODS</b></p><p>Each GIC was blended with TiO2 nanopowder, anatase phase, particle size <25 nm at 3% and 5% (w/w), and the GIC blocks of cements were prepared in a metal mold. The GICs/TiO2 nanoparticles cements were smashed up with a mortar and pestle to a fine powder, and then subjected to the sterilization by autoclaving. Human oral squamous cell carcinoma cell lines (HCS-2, HSC-3, HSC-4, Ca9-22) and human normal oral cells [gingival fibroblast (HGF), pulp (HPC) and periodontal ligament fibroblast (HPLF)] were incubated with different concentrations of GICs in the presence or absence of TiO2 nanoparticles, and the viable cell number was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Prostaglandin E2 was quantified by enzyme-linked immunosorbent assay (ELISA). Changes in fine cell structure were assessed by transmission electron microscopy.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Cancer cells exhibited moderate cytotoxicity after 48 h of incubation, regardless of the type of GIC and the presence or absence of TiO2 NPs. GICs induced much lower cytotoxicity against normal cells, but induced prostaglandin E2 production, in a synergistic wanner with interleukin-1β.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>The present study shows acceptable to moderate biocompatibility of GICs impregnated with TiO2 nanoparticles, as well as its pro-inflammatory effects at higher concentrations.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25189906</PMID><DateCompleted><Year>2015</Year><Month>05</Month><Day>22</Day></DateCompleted><DateRevised><Year>2014</Year><Month>09</Month><Day>05</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1791-7549</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>5</Issue><PubDate><MedlineDate>2014 Sep-Oct</MedlineDate></PubDate></JournalIssue><Title>In vivo (Athens, Greece)</Title><ISOAbbreviation>In Vivo</ISOAbbreviation></Journal><ArticleTitle>Effects of TiO2 nano glass ionomer cements against normal and cancer oral cells.</ArticleTitle><Pagination><MedlinePgn>895-907</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND/AIM" NlmCategory="OBJECTIVE">Incorporation of nanoparticles (NPs) into the glass ionomer cements (GICs) is known to improve their mechanical and antibacterial properties. The present study aimed to investigate the possible cytotoxicity and pro-inflammation effect of three different powdered GICs (base, core build and restorative) prepared with and without titanium dioxide (TiO2) nanoparticles.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Each GIC was blended with TiO2 nanopowder, anatase phase, particle size <25 nm at 3% and 5% (w/w), and the GIC blocks of cements were prepared in a metal mold. The GICs/TiO2 nanoparticles cements were smashed up with a mortar and pestle to a fine powder, and then subjected to the sterilization by autoclaving. Human oral squamous cell carcinoma cell lines (HCS-2, HSC-3, HSC-4, Ca9-22) and human normal oral cells [gingival fibroblast (HGF), pulp (HPC) and periodontal ligament fibroblast (HPLF)] were incubated with different concentrations of GICs in the presence or absence of TiO2 nanoparticles, and the viable cell number was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. Prostaglandin E2 was quantified by enzyme-linked immunosorbent assay (ELISA). Changes in fine cell structure were assessed by transmission electron microscopy.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Cancer cells exhibited moderate cytotoxicity after 48 h of incubation, regardless of the type of GIC and the presence or absence of TiO2 NPs. GICs induced much lower cytotoxicity against normal cells, but induced prostaglandin E2 production, in a synergistic wanner with interleukin-1β.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The present study shows acceptable to moderate biocompatibility of GICs impregnated with TiO2 nanoparticles, as well as its pro-inflammatory effects at higher concentrations.</AbstractText><CopyrightInformation>Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Garcia-Contreras</LastName><ForeName>Rene</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Dental and Advanced Studies Research Center, Faculty of Dentistry, Autonomous University State of Mexico, Toluca, Mexico Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan sakagami@dent.meikai.ac.jp dentist.garcia@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scougall-Vilchis</LastName><ForeName>Rogelio J</ForeName><Initials>RJ</Initials><AffiliationInfo><Affiliation>Department of Orthodontics, Faculty of Dentistry, Autonomous University State of Mexico, Toluca, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Contreras-Bulnes</LastName><ForeName>Rosalia</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Pediatric Dentistry, Faculty of Dentistry, Autonomous University State of Mexico, Toluca, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanda</LastName><ForeName>Yumiko</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Electron Microscopy, Meikai University School of Dentistry, Sakado, Saitama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakajima</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Dental Biomaterials Science, Meikai University School of Dentistry, Sakado, Saitama, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sakagami</LastName><ForeName>Hiroshi</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan sakagami@dent.meikai.ac.jp dentist.garcia@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Greece</Country><MedlineTA>In Vivo</MedlineTA><NlmUniqueID>8806809</NlmUniqueID><ISSNLinking>0258-851X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005899">Glass Ionomer Cements</NameOfSubstance></Chemical><Chemical><RegistryNumber>15FIX9V2JP</RegistryNumber><NameOfSubstance UI="C009495">titanium dioxide</NameOfSubstance></Chemical><Chemical><RegistryNumber>D1JT611TNE</RegistryNumber><NameOfSubstance UI="D014025">Titanium</NameOfSubstance></Chemical><Chemical><RegistryNumber>K7Q1JQR04M</RegistryNumber><NameOfSubstance UI="D015232">Dinoprostone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000970" MajorTopicYN="N">Antineoplastic Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002470" MajorTopicYN="N">Cell Survival</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015232" MajorTopicYN="N">Dinoprostone</DescriptorName><QualifierName UI="Q000096" MajorTopicYN="N">biosynthesis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005899" MajorTopicYN="N">Glass Ionomer Cements</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000633" MajorTopicYN="N">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009062" MajorTopicYN="N">Mouth Neoplasms</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053758" MajorTopicYN="N">Nanoparticles</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014025" MajorTopicYN="N">Titanium</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Glass ionomer cements</Keyword><Keyword MajorTopicYN="N">TiO2 nanoparticles</Keyword><Keyword MajorTopicYN="N">cytotoxicity</Keyword><Keyword MajorTopicYN="N">prostaglandin E2</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>9</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>5</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25189906</ArticleId><ArticleId IdType="pii">28/5/895</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Japon</li><li>Mexique</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Garcia Contreras, Rene" sort="Garcia Contreras, Rene" uniqKey="Garcia Contreras R" first="Rene" last="Garcia-Contreras">Rene Garcia-Contreras</name></noRegion><name sortKey="Kanda, Yumiko" sort="Kanda, Yumiko" uniqKey="Kanda Y" first="Yumiko" last="Kanda">Yumiko Kanda</name><name sortKey="Nakajima, Hiroshi" sort="Nakajima, Hiroshi" uniqKey="Nakajima H" first="Hiroshi" last="Nakajima">Hiroshi Nakajima</name><name sortKey="Sakagami, Hiroshi" sort="Sakagami, Hiroshi" uniqKey="Sakagami H" first="Hiroshi" last="Sakagami">Hiroshi Sakagami</name></country><country name="Mexique"><noRegion><name sortKey="Scougall Vilchis, Rogelio J" sort="Scougall Vilchis, Rogelio J" uniqKey="Scougall Vilchis R" first="Rogelio J" last="Scougall-Vilchis">Rogelio J. Scougall-Vilchis</name></noRegion><name sortKey="Contreras Bulnes, Rosalia" sort="Contreras Bulnes, Rosalia" uniqKey="Contreras Bulnes R" first="Rosalia" last="Contreras-Bulnes">Rosalia Contreras-Bulnes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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